CHTOP antibody (AA 31-130) (AbBy Fluor® 488)

Catalog No. ABIN1695172

Product Details anti-CHTOP Antibody (AbBy Fluor® 488)

Target: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Binding Specificity: AA 31-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHTOP antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C1orf77

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CHTOP

Target: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Alternative Name: C1orf77 (CHTOP Products)

Synonyms: C1orf77 antibody, FL-SRAG antibody, FOP antibody, RP1-178F15.2 antibody, SRAG antibody, SRAG-3 antibody, SRAG-5 antibody, pp7704 antibody, 2500003M10Rik antibody, C81330 antibody, Fop antibody, Srag antibody, C25H1orf77 antibody, C3H1orf77 antibody, c1orf77 antibody, chtop antibody, fop antibody, srag antibody, fb17a05 antibody, wu:fb17a05 antibody, wu:fi05e09 antibody, zgc:55292 antibody, zgc:153909 antibody, chromatin target of PRMT1 antibody, chromatin target of PRMT1 S homeolog antibody, chromatin target of PRMT1 protein antibody, chromatin target of PRMT1a antibody, chromatin target of PRMT1b antibody, CHTOP antibody, Chtop antibody, chtop.S antibody, LOC100344922 antibody, chtopa antibody, chtopb antibody

Background:

Synonyms: Chromatin target of PRMT1 protein, Chromosome 1 open reading frame 77, CHTOP, CHTOP_HUMAN, DKFZp547E1010, FOP, Friend of PRMT1 protein, MGC131924, MGC86949, OTTHUMP00000035122, OTTHUMP00000035123, Pp7704, RP1 178F15.2, Small arginine- and glycine-rich protein, Small protein rich in arginine and glycine, SRAG.

Background: C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of _-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.

Gene ID: 26097