IQSEC2 antibody (AA 851-950) (AbBy Fluor® 488)
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- Target See all IQSEC2 Antibodies
- IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
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Binding Specificity
- AA 851-950
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IQSEC2 antibody is conjugated to AbBy Fluor® 488
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat,Dog,Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human IQSEC2
- Isotype
- IgG
- Top Product
- Discover our top product IQSEC2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
- Alternative Name
- IQSEC2 (IQSEC2 Products)
- Synonyms
- BRAG1 antibody, MRX1 antibody, Brag1 antibody, mKIAA0522 antibody, RGD1562109 antibody, IQ motif and Sec7 domain 2 antibody, IQSEC2 antibody, Iqsec2 antibody
- Background
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Synonyms: BRAG1, IQ mot and SEC7 domain-containing protein 2, IQEC2_HUMAN, Iqsec2, KIAA0522, mKIAA0522, MRX1, RP11-258C19.1.
Background: IQSEC2 is a 1,478 amino acid protein that belongs to the BRAG family and contains one IQ domain, one PH domain and a SEC7 domain. Localizing to the cytoplasm, IQSEC2 is expressed in brain, kidney and small intestine, with weaker levels of expression in placenta, pancreas, ovary, prostate and liver. IQSEC2 is a component of the postsynaptic density at excitatory synapses, and interacts with ARF family members as a guanine nucleotide exchange factor. Through the activation of ARF substrates, IQSEC2 may play a crucial role in cytoskeletal and synaptic organization. The gene encoding IQSEC2 maps to the human X chromosome. Defects to the IQSEC2 gene have been linked to mental retardation X-linked type 1 (MRX1), a condition characterized by decreased intellectual function. IQSEC2 exists as three isoforms due to alternative splicing events.
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