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AFAP1L2 antibody (AbBy Fluor® 488)

AFAP1L2 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1694742
  • Target See all AFAP1L2 Antibodies
    AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
    Reactivity
    • 20
    • 19
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    • 2
    Rabbit
    Clonality
    • 21
    • 2
    Polyclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AFAP1L2 antibody is conjugated to AbBy Fluor® 488
    Application
    • 23
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AFAP1L2
    Isotype
    IgG
    Top Product
    Discover our top product AFAP1L2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
    Alternative Name
    Afap1l2 (AFAP1L2 Products)
    Synonyms
    KIAA1914 antibody, XB130 antibody, AU041783 antibody, C86904 antibody, mKIAA1914 antibody, RGD1310668 antibody, actin filament associated protein 1 like 2 antibody, actin filament associated protein 1-like 2 antibody, AFAP1L2 antibody, Afap1l2 antibody
    Background

    Synonyms: KIAA1914, XB130, Actin filament-associated protein 1-like 2, AF1L2_HUMAN, AFAP1-like protein 2, afap1l2.

    Background: Actin filament associated protein (AFAP-110) interacts directly with actin filaments through its C-terminal actin-binding domain. AFAP-110 contains additional protein-binding domains as well, and serves as an adaptor protein. By linking signaling molecules to actin filaments, AFAP-110 provides a platform for the preparation of larger signaling complexes, activates Src kinases in response to cellular signals and also directly affects Actin organization as an Actin filament cross-linking protein. AFAP-1L2 (Actin filament-associated protein 1-like 2), also known as XB130, is a 818 amino acid cytoplasmic protein that contains two Pleckstrin homology (PH) domains, which are normally found in proteins involved in intracellular signaling. Like its relative AFAP110, AFAP-1L2 interacts with Src kinase and may play a role in Src-regulated transcription activation. AFAP-1L2 is expressed in thyroid and spleen and can also be detected at lower levels in lung, brain, pancreas and kidney. There are four isoforms of AFAP-1L2 that are produced as a result of alternative splicing events.

    Pathways
    EGFR Signaling Pathway
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