Orexin A antibody (AbBy Fluor® 488)

Catalog No. ABIN1694609

Product Details anti-Orexin A Antibody (AbBy Fluor® 488)

Target: Orexin A (OXA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Orexin A antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Orexin A

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Orexin A

Target: Orexin A (OXA)

Alternative Name: Orexin A (OXA Products)

Synonyms: PPOX antibody, orexin-A antibody, hypocretin antibody, hypocretin neuropeptide precursor antibody, Hcrt antibody, HCRT antibody

Background:

Synonyms: HCRT 1, HCRT, HCRT1, HCRT2, Hypocretin orexin neuropeptide precursor, Hypocretin 1, Hypocretin 2, Hypocretin A, Hypocretin, Hypocretin neuropeptide precursor, Hypocretin1, NRCLP1, Orexin A, Orexin, Orexin B, Orexin precursor, OrexinA, OX, PPORX, PPOX, PREPROOREXIN, OREX_HUMAN.

Background: Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B (hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy.

Gene ID: 3060

Pathways: Synaptic Membrane, Feeding Behaviour