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Hephaestin antibody (AA 21-120) (AbBy Fluor® 350)

HEPH Reactivity: Human, Mouse WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 350
Catalog No. ABIN1694317
  • Target See all Hephaestin (HEPH) Antibodies
    Hephaestin (HEPH)
    Binding Specificity
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 21-120
    Reactivity
    • 24
    • 18
    • 5
    Human, Mouse
    Host
    • 22
    • 3
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Hephaestin antibody is conjugated to AbBy Fluor® 350
    Application
    • 24
    • 12
    • 12
    • 10
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Hephaestin
    Isotype
    IgG
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    Discover our top product HEPH Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Hephaestin (HEPH)
    Alternative Name
    Hephaestin (HEPH Products)
    Synonyms
    HEPH antibody, C130006F04Rik antibody, Cpl antibody, mKIAA0698 antibody, sla antibody, CPL antibody, hephaestin antibody, HEPH antibody, heph antibody, Heph antibody
    Background

    Synonyms: CPL, HEPH, HEPH_HUMAN, Hephaestin.

    Background: Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.

    Gene ID
    9843
    Pathways
    Transition Metal Ion Homeostasis
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