GALNT11 antibody (AA 401-500) (AbBy Fluor® 350)

Catalog No. ABIN1693681

Product Details anti-GALNT11 Antibody (AbBy Fluor® 350)

Target: GALNT11 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 11 (GalNAc-T11) (GALNT11))

Binding Specificity: AA 401-500

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALNT11 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GALNT11/GalNAc-T11

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GALNT11

Target: GALNT11 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 11 (GalNAc-T11) (GALNT11))

Alternative Name: GALNT11/GalNAc-T11 (GALNT11 Products)

Synonyms: A430075I06Rik antibody, AI648252 antibody, E430002F06Rik antibody, GALNACT11 antibody, polypeptide N-acetylgalactosaminyltransferase 11 antibody, Galnt11 antibody, GALNT11 antibody

Background:

Synonyms: A430075I06Rik, AI648252, E430002F06Rik, FLJ21634, GalNAc-T11, GALNT11, GLT11_HUMAN, MGC71630, Polypeptide GalNAc transferase 11, Polypeptide N-acetylgalactosaminyltransferase 11, pp-GaNTase 11, Protein-UDP acetylgalactosaminyltransferase 11, tcag7.1057, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11.

Background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T11 (Polypeptide N-acetylgalactosaminyltransferase 11), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11, is a 608 amino acid protein that catalyzes glycosylation of Muc1, Muc4.1 and EA2, though it does not display enzymatic preference for erythropoitein. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. GalNAc-T11 is highly expressed in kidney tubules, though it is not expressed in glomeruli. There are two isoforms of GalNAc-T11 that are produced as a result of alternative splicing events.

Gene ID: 63917