FERMT2 antibody (AA 352-420) (AbBy Fluor® 350)

Catalog No. ABIN1693440

Product Details anti-FERMT2 Antibody (AbBy Fluor® 350)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Binding Specificity: AA 352-420

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT2 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kindlin 2/MIG2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Alternative Name: Kindlin 2/MIG2 (FERMT2 Products)

Synonyms: AA960555 antibody, Kindlin-2 antibody, Mig2 antibody, Plekhc1 antibody, KIND2 antibody, MIG2 antibody, PLEKHC1 antibody, UNC112 antibody, UNC112B antibody, mig-2 antibody, fermitin family member 2 antibody, Fermt2 antibody, FERMT2 antibody

Background:

Synonyms: FLJ34213, FLJ44462, UNC112, FERM2_HUMAN, Fermitin family homolog 2, Fermt2, KIND2, Kindlin-2, MIG-2, MIG2, Mitogen-inducible gene 2 protein, PH domain-containing family C member 1, Pleckstrin homology domain containing family C with FERM domain member 1, Pleckstrin homology domain-containing family C member 1, PLEKHC1, UNC112B.

Background: Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues.

Gene ID: 10979

Pathways: Cell-Cell Junction Organization