CLCNKB antibody (AA 51-150) (AbBy Fluor® 350)

Catalog No. ABIN1692979

Product Details anti-CLCNKB Antibody (AbBy Fluor® 350)

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKB antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLCNKB

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLCNKB

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Alternative Name: CLCNKB (CLCNKB Products)

Synonyms: CLCNKA antibody, CLCNKB antibody, DKFZp469N0132 antibody, CLCKB antibody, Clc-Ka antibody, Clck2 antibody, Clcnk1l antibody, ClC-K2L antibody, ClC-K2 antibody, ClC-Kb antibody, ClC-k antibody, clc-kb antibody, clckb antibody, clcnka-A antibody, clk-k2 antibody, x6clck antibody, xCIC-K antibody, xClC-K antibody, zgc:64141 antibody, Clcnkb antibody, chloride voltage-gated channel Kb antibody, chloride channel Kb antibody, chloride channel, voltage-sensitive Kb antibody, chloride channel, voltage-sensitive Kb L homeolog antibody, chloride channel K antibody, chloride channel protein ClC-Ka antibody, chloride channel protein ClC-Kb antibody, CLCNKB antibody, Clcnkb antibody, clcnkb.L antibody, clcnk antibody, LOC100017912 antibody, LOC100400180 antibody, LOC100590605 antibody, LOC100730738 antibody

Background:

Synonyms: Bartter syndrome type 3, Chloride channel Kb, Chloride channel kidney B, Chloride channel protein ClC-Kb, Chloride channel voltage sensitive Kb, ClC K2, ClC-K2, ClCK2, CLCKB, CLCKB_HUMAN, CLCNKB, hClC Kb, hClCKb, MGC24087, OTTHUMP00000011120, OTTHUMP00000011121, RP11 5P18.8.

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter?s syndrome which is characterized by renal salt-wasting and low blood pressure.