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Chloride Channel 5 antibody (AA 1-100) (AbBy Fluor® 350)

CLCN5 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 350
Catalog No. ABIN1692977
  • Target See all Chloride Channel 5 (CLCN5) Antibodies
    Chloride Channel 5 (CLCN5)
    Binding Specificity
    • 14
    • 14
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 48
    • 14
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 48
    • 1
    Rabbit
    Clonality
    • 49
    Polyclonal
    Conjugate
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Chloride Channel 5 antibody is conjugated to AbBy Fluor® 350
    Application
    • 23
    • 22
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Chloride Channel 5/CLC5
    Isotype
    IgG
    Top Product
    Discover our top product CLCN5 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Chloride Channel 5 (CLCN5)
    Alternative Name
    Chloride Channel 5 (CLCN5 Products)
    Synonyms
    CLCN3 antibody, CLCN5 antibody, clcn5-A antibody, DKFZp469O2315 antibody, 5430408K11Rik antibody, ClC-5 antibody, Clc5 antibody, D930009B12Rik antibody, DXImx42e antibody, Sfc13 antibody, T25545 antibody, CLC5 antibody, CLCK2 antibody, DENTS antibody, NPHL1 antibody, NPHL2 antibody, XLRH antibody, XRN antibody, hCIC-K2 antibody, CLCN4 antibody, Clcn5 antibody, chloride voltage-gated channel 5 antibody, chloride channel, voltage-sensitive 5 L homeolog antibody, chloride channel, voltage-sensitive 5 antibody, CLCN5 antibody, clcn5.L antibody, clcn5 antibody, Clcn5 antibody
    Background

    Synonyms: Chloride channel protein 5, Chloride transporter ClC-5, ClC-5, CLC5, CLCK2, CLCN5, CLCN5_HUMAN, DENTS, H+/Cl- exchange transporter 5, hCIC-K2, NPHL1, NPHL2, XLRH, XRN.

    Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent?s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.

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