ADRA2C antibody (AA 442-462)

Catalog No. ABIN1686644

Product Details anti-ADRA2C Antibody

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Binding Specificity: AA 442-462

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADRA2C antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: Detects 50 kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.

Cross-Reactivity: Human, Mouse

Purification: Protein G Purified

Immunogen: Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor

Clone: S330A-80

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN1686644 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 μg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for ADRA2C

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Alternative Name: Alpha2C Adrenergic (ADRA2C Products)

Synonyms: ADRA2L2 antibody, ADRA2RL2 antibody, ADRARL2 antibody, ALPHA2CAR antibody, Adra-2c antibody, [a]2C antibody, alpha2-C4 antibody, alpha2C antibody, zgc:194523 antibody, zgc:194541 antibody, adra2c antibody, ADRA2B antibody, ADRA2C antibody, adrenoceptor alpha 2C antibody, adrenergic receptor, alpha 2c antibody, ADRA2C antibody, Adra2c antibody, adra2c antibody

Background: The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.

Gene ID: 152

NCBI Accession: NP_000674

UniProt: P18825

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process