STING/TMEM173 antibody (AA 170-379)

Catalog No. ABIN6220283

Product Details anti-STING/TMEM173 Antibody

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Binding Specificity: AA 170-379

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Sequence: LILPELQARI RTYNQHYNNL LRGAVSQRLY ILLPLDCGVP DNLSMADPNI RFLDKLPQQT GDHAGIKDRV YSNSIYELLE NGQRAGTCVL EYATPLQTLF AMSQYSQAGF SREDRLEQAK LFCRTLEDIL ADAPESQNNC RLIAYQEPAD DSSFSLSQEV LRHLRQEEKE EVTVGSLKTS AVPSTSTMSQ EPELLISGME KPLPLRTDFS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-379 of human STING/TMEM173 (NP_938023.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: STING (TMEM173 Products)

Synonyms: ERIS antibody, MITA antibody, MPYS antibody, NET23 antibody, STING antibody, 2610307O08Rik antibody, Mita antibody, RGD1562552 antibody, transmembrane protein 173 antibody, TMEM173 antibody, Tmem173 antibody

Background: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.,TMEM173,ERIS,MITA,MPYS,NET23,SAVI,STING,hMITA,hSTING,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,STING

Molecular Weight: 42 kDa

Gene ID: 340061

UniProt: Q86WV6

Pathways: Activation of Innate immune Response