TIMELESS antibody (AA 969-1208)

Catalog No. ABIN1683038

Product Details anti-TIMELESS Antibody

Target: TIMELESS (Timeless Homolog (TIMELESS))

Binding Specificity: AA 969-1208

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMELESS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EDLEEEENLP EEDSEEEEEG GSEAEQVQGS LVLSNENLGQ SLHQEGFSIP LLWLQNCLIR AADDREEDGC SQAVPLVPLT EENEEAMENE QFQQLLRKLG VRPPASGQET FWRIPAKLSP TQLRRAAASL SQPEEEQKLQ PELQPKVPGE QGSDEEHCKE HRAQALRALL LAHKKKAGLA SPEEEDAVGK EPLKAAPKKR QLLDSDEEQE EDEGRNRAPE LGAPGIQKKK RYQIEDDEDD

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 969-1208 of human TIMELESS (NP_003911.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Alternative Name: TIMELESS (TIMELESS Products)

Background: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.,TIMELESS,TIM,TIM1,hTIM,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Apoptosis,TIMELESS

Molecular Weight: 138 kDa

Gene ID: 8914

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism