SNAIL antibody (AA 1-100)

Catalog No. ABIN1682836

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Snail (NP_005976.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SNAIL antibody (ABIN1682836)

Yang, Qiu, Xiao, Hu, Liu, Chen, Huang, Li, Li, Zhang, Ding, Xiang: "AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition." in: Theranostics, Vol. 8, Issue 13, pp. 3707-3721, (2018) (PubMed).

Wang, Dong, Wang, Li, Dong, Jeyalatha, Wu, Shen, Yang, Chen, Xue, Liu, Li: "Epithelial dysplasia in pterygium postoperative granuloma." in: Experimental eye research, Vol. 175, pp. 199-206, (2018) (PubMed).

Du, Fang, Chen, Teng, Xiao, Xie, Jin, Wang: "Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 6050-6058, (2018) (PubMed).

Zhan, Chen, Chen: "Knockdown of FUT3 disrupts the proliferation, migration, tumorigenesis and TGF-β induced EMT in pancreatic cancer cells." in: Oncology letters, Vol. 16, Issue 1, pp. 924-930, (2018) (PubMed).

Chen, Zheng, Liu, Shi, Qi: "Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma." in: Journal of the neurological sciences, Vol. 360, pp. 49-54, (2016) (PubMed).

Xu, Zhu, Zhao, Chen, Zhang, Yuan, Deng, Dou, Wang, Huang, Chen, Jiang, Yu: "Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors." in: Oncotarget, Vol. 6, Issue 2, pp. 979-94, (2015) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 (SNAI1 Products)

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, AI194338 antibody, Sna antibody, Sna1 antibody, Snail antibody, Snail1 antibody, SNAI1 antibody, BG:DS01845.1 antibody, CG3956 antibody, Dmel\\CG3956 antibody, Sco antibody, br28 antibody, br29 antibody, l(2)35Db antibody, l(2)br28 antibody, l(2)br29 antibody, l(3)br28 antibody, l35Db antibody, sn antibody, Xsnail antibody, sna antibody, snail1 antibody, xSna antibody, Snai antibody, sna2 antibody, snail2 antibody, cb643 antibody, sna-1 antibody, sna1 antibody, snai1 antibody, snail1a antibody, zgc:109820 antibody, snail family transcriptional repressor 1 antibody, snail family zinc finger 1 antibody, snail homolog 1 (Drosophila) antibody, snail antibody, zinc-finger transcription factor Snail antibody, snail family zinc finger 1 S homeolog antibody, protein escargot antibody, transcription factor protein antibody, snail zinc finger protein antibody, snail family zinc finger 1b antibody, snail family zinc finger 1a antibody, SNAI1 antibody, Snai1 antibody, sna antibody, snail antibody, snai1.S antibody, LOC410464 antibody, snai1b antibody, snai1a antibody

Background: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.,SNAI1,SLUGH2,SNA,SNAH,SNAIL,SNAIL1,dJ710H13.1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Cardiovascular,Heart,Cardiogenesis,SNAI1

Molecular Weight: 29 kDa

Gene ID: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling