SMC5 antibody (AA 872-1101)

Catalog No. ABIN1682829

Product Details anti-SMC5 Antibody

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Binding Specificity: AA 872-1101

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LTEERSRASC FTGLNPTIVQ EYTKREEEIE QLTEELKGKK VELDQYRENI SQVKERWLNP LKELVEKINE KFSNFFSSMQ CAGEVDLHTE NEEDYDKYGI RIRVKFRSST QLHELTPHHQ SGGERSVSTM LYLMALQELN RCPFRVVDEI NQGMDPINER RVFEMVVNTA CKENTSQYFF ITPKLLQNLP YSEKMTVLFV YNGPHMLEPN TWNLKAFQRR RRRITFTQPS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 872-1101 of human SMC5 (NP_055925.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:3000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMC5

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Alternative Name: SMC5 (SMC5 Products)

Synonyms: F1N13.60 antibody, F1N13_60 antibody, structural maintenance of chromosomes 5 antibody, SMC-5 antibody, SMC5L1 antibody, MLZ-453 antibody, Smc5l1 antibody, mKIAA0594 antibody, mSMC5 antibody, structural maintenance of chromosomes 5 antibody, structural maintenance of chromosomes 5 S homeolog antibody, SMC5 antibody, smc5 antibody, Smc5 antibody, smc5.S antibody

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.,SMC5,SMC5L1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,SMC5

Molecular Weight: 128 kDa

Gene ID: 23137

UniProt: Q8IY18