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PPP2R4 antibody (AA 1-323)
PPP2R4
Reactivity: Human
IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PPP2R4 Antibody
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Target
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PPP2R4
(Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))
Binding Specificity
All epitopes for PPP2R4 antibodies
AA 1-323
Reactivity
All reactivities for PPP2R4 antibodies
Human
Host
All hosts for PPP2R4 antibodies
Rabbit
Clonality
All clonalities for PPP2R4 antibodies
Polyclonal
Conjugate
All conjugates for PPP2R4 antibodies
This PPP2R4 antibody is un-conjugated
Application
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Immunofluorescence (IF)
Sequence
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK GKKLTFEYRV SEAIEKLVAL LNTLDRWIDE TPPVDQPSRF GNKAYRTWYA KLDEEAENLV ATVVPTHLAA AVPEVAVYLK ESVGNSTRID YGTGHEAAFA AFLCCLCKIG VLRVDDQIAI VFKVFNRYLE VMRKLQKTYR MEPAGSQGVW GLDDFQFLPF IWGSSQLIDH PYLEPRHFVD EKAVNENHKD YMFLECILFI TEMKTGPFAE HSNQLWNISA VPSWSKVNQG LIRMYKAECL EKFPVIQHFK FGSLLPIHPV TSG
Cross-Reactivity
Human, Mouse
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Ser/thr-PP2A activator (PTPA) (NP_821067.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
IF,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-PPP2R4 antibody (ABIN1682265)
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Jiang, Cao, Wang, Li, Liu, Lv, Li, Mi : "Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. " in: Theranostics , Vol. 7 , Issue 4 , pp. 1036-1046 , (2017 ) (PubMed ).
Wang, Gan, Wang, Wu, Cao, Zhu, Xu, Wang, Han, Li, Ye, Zhao, Mi : "Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy. " in: EBioMedicine , Vol. 17 , pp. 45-56 , (2017 ) (PubMed ).
Target Details for PPP2R4
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Target
PPP2R4
(Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))
Alternative Name
PPP2R4 (PPP2R4 Products )
Synonyms
PP2A antibody, PR53 antibody, PTPA antibody, 2610042B21Rik antibody, C77440 antibody, N28142 antibody, PTPRA antibody, Ppp2r4 antibody, fc23d07 antibody, ppp2r4 antibody, wu:fc23d07 antibody, zgc:92766 antibody, pp2a antibody, ppp2r4.L antibody, pr53 antibody, ptpa antibody, protein phosphatase 2 phosphatase activator antibody, protein phosphatase 2 protein activator antibody, protein phosphatase 2 phosphatase activator L homeolog antibody, PTPA antibody, Ptpa antibody, ptpa antibody, ptpa.L antibody
Background
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.,PTPA,PP2A,PPP2R4,PR53,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,PPP2R4
Molecular Weight
31 kDa/33 kDa/36 kDa/40 kDa
Gene ID
5524
UniProt
Q15257
Pathways
PI3K-Akt Signaling , M Phase , Hepatitis C , Toll-Like Receptors Cascades
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