POLI antibody (AA 50-350)

Catalog No. ABIN1682214

Product Details anti-POLI Antibody

Target: POLI (Polymerase (DNA Directed) iota (POLI))

Binding Specificity: AA 50-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLI antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ASSRVIVHVD LDCFYAQVEM ISNPELKDKP LGVQQKYLVV TCNYEARKLG VKKLMNVRDA KEKCPQLVLV NGEDLTRYRE MSYKVTELLE EFSPVVERLG FDENFVDLTE MVEKRLQQLQ SDELSAVTVS GHVYNNQSIN LLDVLHIRLL VGSQIAAEMR EAMYNQLGLT GCAGVASNKL LAKLVSGVFK PNQQTVLLPE SCQHLIHSLN HIKEIPGIGY KTAKCLEALG INSVRDLQTF SPKILEKELG ISVAQRIQKL SFGEDNSPVI LSGPPQSFSE EDSFKKCSSE VEAKNKIEEL L

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human POLI (NP_009126.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-POLI antibody (ABIN1682214)

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Target Details for POLI

Target: POLI (Polymerase (DNA Directed) iota (POLI))

Alternative Name: POLI (POLI Products)

Synonyms: poli antibody, wu:fc27h11 antibody, zgc:110185 antibody, GB12093 antibody, NV16187 antibody, RAD30B antibody, RAD3OB antibody, Rad30b antibody, DNA polymerase iota antibody, polymerase (DNA directed) iota antibody, polymerase (DNA directed), iota antibody, POLI antibody, poli antibody, LOC551219 antibody, AFUA_4G11140 antibody, LOC5568276 antibody, Pol-iota antibody, Poli antibody

Background: The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion.,POLI,RAD30B,RAD3OB,eta2,Epigenetics & Nuclear Signaling,POLI

Molecular Weight: 83 kDa

Gene ID: 11201

UniProt: Q9UNA4

Pathways: DNA Damage Repair