NPLOC4 antibody (AA 1-270)

Catalog No. ABIN1681086

Product Details anti-NPLOC4 Antibody

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Binding Specificity: AA 1-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPLOC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MAESIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR NKTGEITASS NKSLNLLKIK HGDLLFLFPS SLAGPSSEME TSVPPGFKVF GAPNVVEDEI DQYLSKQDGK IYRSRDPQLC RHGPLGKCVH CVPLEPFDED YLNHLEPPVK HMSFHAYIRK LTGGADKGKF VALENISCKI KSGCEGHLPW PNGICTKCQP SAITLNRQKY RHVDNIMFEN HTVADRFLDF WRKTGNQHFG YLYGRYTEHK DIPLGIRAEV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human NPLOC4 (NP_060391.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NPLOC4

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Alternative Name: NPLOC4 (NPLOC4 Products)

Synonyms: NPL4 antibody, AK129375 antibody, Npl4 antibody, mKIAA1499 antibody, NPL4 homolog, ubiquitin recognition factor antibody, NPLOC4 antibody, Nploc4 antibody

Background: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I.,NPLOC4,NPL4,NPL4 homolog,Signal Transduction,NPLOC4

Molecular Weight: 68 kDa/69 kDa

Gene ID: 55666

UniProt: Q8TAT6