Ubiquitin B antibody

Catalog No. ABIN7101530

Product Details anti-Ubiquitin B Antibody

Target: Ubiquitin B (UBB)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Ubiquitin B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human K48-linkage Specific Ubiquitin

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000, IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Ubiquitin B

Target: Ubiquitin B (UBB)

Alternative Name: UBB (UBB Products)

Synonyms: AL033289 antibody, Rps27a antibody, Uba52 antibody, Ubb2 antibody, Ubc antibody, UBC antibody, Ubiquitin antibody, UBB antibody, Ubi-p63E antibody, im:6892314 antibody, si:ch211-202a12.3 antibody, ubc antibody, zUBC antibody, zgc:172187 antibody, ubiquitin B antibody, ubiquitin C antibody, UBB antibody, Ubb antibody, UBC antibody, ubb antibody

Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],HEL-S-50,Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cell Biology & Developmental Biology,Epigenetics & Nuclear Signaling,Neurodegenerative Diseases,Neurodegenerative Diseases_Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Neuroscience,Ubiquitin,Ubiquitin_Ubiquitin-Proteasome Signaling Pathway,UBB

Gene ID: 7314

UniProt: P0CG47

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagy, EGFR Downregulation, Ubiquitin Proteasome Pathway