GUCY2D antibody (AA 52-350)

Catalog No. ABIN1680144

Product Details anti-GUCY2D Antibody

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Binding Specificity: AA 52-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY2D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AVFTVGVLGP WACDPIFSRA RPDLAARLAA ARLNRDPGLA GGPRFEVALL PEPCRTPGSL GAVSSALARV SGLVGPVNPA ACRPAELLAE EAGIALVPWG CPWTQAEGTT APAVTPAADA LYALLRAFGW ARVALVTAPQ DLWVEAGRSL STALRARGLP VASVTSMEPL DLSGAREALR KVRDGPRVTA VIMVMHSVLL GGEEQRYLLE AAEELGLTDG SLVFLPFDTI HYALSPGPEA LAALANSSQL RRAHDAVLTL TRHCPSEGSV LDSLRRAQER RELPSDLNLQ QVSPLFGTI

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 52-350 of human GUCY2D (NP_000171.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GUCY2D

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Alternative Name: GUCY2D (GUCY2D Products)

Background: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.,GUCY2D,CORD5,CORD6,CYGD,GUC1A4,GUC2D,LCA,LCA1,RCD2,RETGC-1,ROS-GC1,ROSGC,retGC,Signal Transduction,Neuroscience,GUCY2D

Molecular Weight: 120 kDa

Gene ID: 3000

UniProt: Q02846

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction