GTPBP4 antibody (AA 385-634)

Catalog No. ABIN1680142

Product Details anti-GTPBP4 Antibody

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Binding Specificity: AA 385-634

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTPBP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: RKRMETEESR KKRERDLELE MGDDYILDLQ KYWDLMNLSE KHDKIPEIWE GHNIADYIDP AIMKKLEELE KEEELRTAAG EYDSVSESED EEMLEIRQLA KQIREKKKLK ILESKEKNTQ GPRMPRTAKK VQRTVLEKEM RSLGVDMDDK DDAHYAVQAR RSRSITRKRK REDSAPPSSV ARSGSCSRTP RDVSGLRDVK MVKKAKTMMK NAQKKMNRLG KKGEADRHVF DMKPKHLLSG KRKAGKKDRR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 385-634 of human GTPBP4 (NP_036473.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GTPBP4

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Alternative Name: GTPBP4 (GTPBP4 Products)

Background: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.,GTPBP4,CRFG,NGB,NOG1,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Tumor suppressors,Signal Transduction,GTPBP4

Molecular Weight: 60 kDa/68 kDa/73 kDa

Gene ID: 23560

UniProt: Q9BZE4