VEGFC antibody

Catalog No. ABIN1589911

Product Details anti-VEGFC Antibody

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: VEGF-C antibody

Specificity: Recombinant rat VEGF-C

Characteristics: Chromosomal location: 16p11
Produced from sera of rabbits immunized with highly pure recombinant rat dNdC-VEGF-C.

Purification: Anti-rat VEGF-C IgG was purified by affinity chromatography with immobilized Protein A.

Immunogen: Recombinant rat VEGF-C (ABIN1589785)

Isotype: IgG

Application Details

Application Notes: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handling Advice: Centrifuge vial prior to opening.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

References for anti-VEGFC antibody (ABIN1589911)

Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: "Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis." in: PLoS ONE, Vol. 9, Issue 9, pp. e106976, (2014) (PubMed).

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: VEGF-C (VEGFC Products)

Synonyms: VEGFC antibody, vegf-c antibody, xvegf-c antibody, Flt4-L antibody, VRP antibody, AW228853 antibody, VEGF-C antibody, vascular endothelial growth factor c antibody, vascular endothelial growth factor C antibody, vascular endothelial growth factor C S homeolog antibody, vegfc antibody, VEGFC antibody, vegfc.S antibody, Vegfc antibody

Background: Vascular endothelial growth factor C, Vegfc,VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

Gene ID: 114111

NCBI Accession: NM_053653, NP_446105

UniProt: O35757

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2