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ALDOC antibody (C-Term)

ALDOC Reactivity: Human, Mouse, Rat, Cow, Pig, Mammalian WB, IHC, IF, ICC Host: Mouse Monoclonal 1A1 unconjugated
Catalog No. ABIN1580409
  • Target See all ALDOC Antibodies
    ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))
    Binding Specificity
    • 9
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 49
    • 30
    • 14
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Pig, Mammalian
    Host
    • 48
    • 7
    Mouse
    Clonality
    • 48
    • 7
    Monoclonal
    Conjugate
    • 35
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALDOC antibody is un-conjugated
    Application
    • 30
    • 17
    • 14
    • 13
    • 9
    • 9
    • 8
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Purification
    affinity purified antibody
    Clone
    1A1
    Isotype
    IgG1
    Top Product
    Discover our top product ALDOC Primary Antibody
  • Application Notes
    The antibody solution can be used at dilutions 1:1,000-2,000 for immunofluorescence. For western blots try at 1:2,000-5,000. A suitable control tissue is brain cell lysates.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4°C short term or -20°C long term.
  • Target
    ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))
    Alternative Name
    Aldolase C (ALDOC Products)
    Synonyms
    ALDC antibody, MGC69434 antibody, ALDOC antibody, aldoc antibody, AI847350 antibody, AU040929 antibody, Aldo3 antibody, Scrg2 antibody, ALDCAA antibody, F16dip7 antibody, RATALDCAA antibody, aldocl antibody, wu:fj56h04 antibody, zgc:112357 antibody, QccE-21970 antibody, aldolase, fructose-bisphosphate C antibody, aldolase, fructose-bisphosphate C L homeolog antibody, aldolase C, fructose-bisphosphate, b antibody, aldolase C, fructose-bisphosphate antibody, aldolase A, fructose-bisphosphate antibody, aldolase C, fructose-bisphosphate, a antibody, Fructose-bisphosphate aldolase C antibody, ALDOC antibody, aldoc.L antibody, aldoc antibody, aldocb antibody, Aldoc antibody, ALDOA antibody, aldoca antibody
    Background
    Aldolases are glycolytic enzymes that catalyze the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively. Three aldolase isozymes are found in mammals, specifically aldolases A, B, and C, each of which is encoded by a separate gene.Aldolase A is generally considered to be a muscle enzyme. Northern analysis of cultured cells suggests that it is present in both neurons and glia. Aldolase B is considered to be a liver-specific enzyme and it is transcriptionally activated by signals from hormones and dietary factors. In the adult, aldolase C is the brain-specific isozyme, with low but detectable activity in fetal tissues. Aldolase C shares 81% amino acid identity with aldolase A and 70% identity with aldolase B. Earlier studies using isozyme-specific antibodies report its location in gray matter astrocytes and cells of the pia mater. In situ hybridization of mouse central nervous system using isozyme-specific probes revealed that aldolase A and C are expressed in complementary cell types: aldolase A mRNA is found in neurons, aldolase C message is detected in astrocytes, some cells of the pia mater, and Purkinje cells. Aldolase C can in some situations be used as an astrocyte marker. However Purkinje cells of the cerebellum contain high levels of the enzyme, so the enzyme is not totally astrocyte specific. MCA-1A1 was raised against C-terminal 23 amino acids of the human aldolase C protein, the sequence is KYEGSGEDGGAAAQSLYIANHAY. The HGNC name for this protein is ALDOC.
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