TMPRSS12 antibody (N-Term)

Catalog No. ABIN1539224

Product Details anti-TMPRSS12 Antibody

Target: TMPRSS12 (Transmembrane (C-terminal) Protease, serine 12 (TMPRSS12))

Binding Specificity: AA 26-54, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS12 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TMPRSS12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TMPRSS12.

Clone: RB35931

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: TMPRSS12 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for TMPRSS12

Target: TMPRSS12 (Transmembrane (C-terminal) Protease, serine 12 (TMPRSS12))

Alternative Name: TMPRSS12 (TMPRSS12 Products)

Synonyms: 4930478A21Rik antibody, transmembrane protease, serine 12 antibody, transmembrane (C-terminal) protease, serine 12 antibody, TMPRSS12 antibody, tmprss12 antibody, Tmprss12 antibody

Background: TMPRSS12 (transmembrane protease serine 12) is a 348 amino acid single-pass membrane protein that belong to the peptidase S1 family and contains one peptidase S1 domain. The gene that encodes TMPRSS12 consists of nearly 45,000 bases and maps to human chromosome 12q13.12. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5 % of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster, encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms which vary in severity depending on the extent of mosaicism.

Molecular Weight: 38605

Gene ID: 283471

NCBI Accession: NP_872365

UniProt: Q86WS5