MASP1 antibody (AA 481-507)

Catalog No. ABIN1538452

Product Details anti-MASP1 Antibody

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Binding Specificity: AA 481-507

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-507 amino acids from the Central region of human MASP1.

Clone: RB22401

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MASP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Alternative Name: MASP1 (MASP1 Products)

Synonyms: AW048060 antibody, CCPII antibody, Crarf antibody, Masp1/3 antibody, 3MC1 antibody, CRARF antibody, CRARF1 antibody, MAP1 antibody, MASP antibody, MASP3 antibody, MAp44 antibody, PRSS5 antibody, RaRF antibody, mannan-binding lectin serine peptidase 1 antibody, mannan binding lectin serine peptidase 1 antibody, Masp1 antibody, MASP1 antibody

Background: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Molecular Weight: 79247

Gene ID: 5648

NCBI Accession: NP_001027019, NP_001870, NP_624302

UniProt: P48740

Pathways: Complement System