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Shugoshin antibody (AA 339-367)

SGOL1 Reactivity: Human WB Host: Rabbit Polyclonal RB36785 unconjugated
Catalog No. ABIN1538328
  • Target See all Shugoshin (SGOL1) Antibodies
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Binding Specificity
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 339-367
    Reactivity
    • 44
    • 5
    • 5
    • 1
    • 1
    Human
    Host
    • 42
    • 3
    Rabbit
    Clonality
    • 43
    • 2
    Polyclonal
    Conjugate
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Shugoshin antibody is un-conjugated
    Application
    • 30
    • 27
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.
    Clone
    RB36785
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SGOL1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    SGOL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Alternative Name
    SGOL1 (SGOL1 Products)
    Synonyms
    sgo1 antibody, NY-BR-85 antibody, SGO antibody, Sgo1 antibody, 3300001M08Rik antibody, C81037 antibody, shugoshin 1 antibody, shugoshin centromeric cohesion 1 antibody, shugoshin 1 L homeolog antibody, Sgo1 antibody, sgo1 antibody, sgo1.L antibody, SGO1 antibody
    Background
    SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
    Molecular Weight
    64190
    Gene ID
    151648
    NCBI Accession
    NP_001012409, NP_001012410, NP_001012411, NP_001012412, NP_001012413, NP_001186180, NP_001186181, NP_001186182, NP_001186183, NP_001186184, NP_001186185, NP_001186186, NP_612493
    UniProt
    Q5FBB7
    Pathways
    Maintenance of Protein Location
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