NTAN1 antibody (C-Term)

Catalog No. ABIN1536839

Product Details anti-NTAN1 Antibody

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Binding Specificity: AA 203-230, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NTAN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NTAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-230 amino acids from the C-terminal region of human NTAN1.

Clone: RB37947

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: NTAN1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for NTAN1

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Alternative Name: NTAN1 (NTAN1 Products)

Synonyms: PNAA antibody, PNAD antibody, N-terminal Asn amidase antibody, N-terminal asparagine amidase antibody, Ntan1 antibody, NTAN1 antibody

Background: Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity).

Gene ID: 123803

NCBI Accession: NP_001257695, NP_001257696, NP_775745

UniProt: Q96AB6