Der1-Like Domain Family, Member 2 (DERL2) (AA 191-219), (C-Term) antibody

Catalog No. ABIN1536818

Product Details

Target: Der1-Like Domain Family, Member 2 (DERL2)

Binding Specificity: AA 191-219, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.

Clone: RB40190

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Mouse Derl2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details

Target: Der1-Like Domain Family, Member 2 (DERL2)

Alternative Name: Derl2 (DERL2 Products)

Background: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).

Molecular Weight: 27640

Gene ID: 116891

NCBI Accession: NP_291040

UniProt: Q8BNI4

Pathways: ER-Nucleus Signaling, Feeding Behaviour