TIMP2 antibody (AA 21-70)

Catalog No. ABIN484039

Product Details anti-TIMP2 Antibody

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Binding Specificity: AA 21-70

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity:

TIMP2 Antibody detects endogenous levels of total TIMP2 protein.

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TIMP2.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Comment:

Unigene-Number: Hs.633514 (NCBI Gene Symbol: TIMP2)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

References for anti-TIMP2 antibody (ABIN484039)

Nishihara, Remacle, Angert, Shubayev, Shiryaev, Liu, Dolkas, Chernov, Strongin, Shubayev: "Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury." in: The Journal of biological chemistry, Vol. 290, Issue 6, pp. 3693-707, (2015) (PubMed).

Hu, Cai, Hu, Patel, Bard, Jamison, Coling: "Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 43, pp. 14927-41, (2012) (PubMed).

Target Details for TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Alternative Name: TIMP2 (TIMP2 Products)

Background:

Synonyms: tissue inhibitor of metalloproteinase 2

NCBI Gene Symbol: TIMP2

Molecular Weight: 24 kDa

Gene ID: 7077

OMIM: 188825

UniProt: P16035

Pathways: cAMP Metabolic Process