PCLO antibody
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- Target See all PCLO Antibodies
- PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PCLO antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human
- Purification
- Protein-A affinity chromatography
- Clone
- PCLO-01
- Isotype
- IgG1
- Top Product
- Discover our top product PCLO Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))
- Alternative Name
- PCLO (PCLO Products)
- Synonyms
- pclo antibody, wu:fj53e09 antibody, Acz antibody, Pico antibody, mKIAA0559 antibody, aczonin antibody, PCLO antibody, ACZ antibody, piccolo presynaptic cytomatrix protein antibody, piccolo presynaptic cytomatrix protein a antibody, piccolo (presynaptic cytomatrix protein) antibody, PCLO antibody, pcloa antibody, Pclo antibody, LOC768552 antibody
- Background
- PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion. Synonyms: ACZ, Aczonin, KIAA0559, Protein piccolo
- Pathways
- Hormone Transport, Synaptic Vesicle Exocytosis
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