Dynamitin antibody (AA 50-320)

Catalog No. ABIN1512818

Product Details anti-Dynamitin Antibody

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Binding Specificity: AA 50-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamitin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: HIIVNPNAAY DKFKDKRVGT KGLDFSDRIG KTKRTGYESG EYEMLGEGLG VKETPQQKYQ RLLHEVQELT TEVEKIKTTV KESATEEKLT PVLLAKQLAA LKQQLVASHL EKLLGPDAAI NLTDPDGALA KRLLLQLEAT KNSKGGSGGK TTGTPPDSSL VTYELHSRPE QDKFSQAAKV AELEKRLTEL ETAVRCDQDA QNPLSAGLQG ACLMETVELL QAKVSALDLA VLDQVEARLQ SVLGKVNEIA KHKASVEDAD TQSKVHQLYE T

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human DCTN2 (NP_006391.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:20 - 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Dynamitin

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Alternative Name: DCTN2 (DCTN2 Products)

Background: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,DCTN2,DCTN50,DYNAMITIN,HEL-S-77,RBP50,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Motor Proteins,Neuroscience,Neurodegenerative Diseases,DCTN2

Molecular Weight: 44 kDa

Gene ID: 10540

UniProt: Q13561

Pathways: M Phase, Ribonucleoprotein Complex Subunit Organization