PHOX2B antibody (Middle Region)
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- Target See all PHOX2B Antibodies
- PHOX2B (Paired-Like Homeobox 2b (PHOX2B))
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Binding Specificity
- Middle Region
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Reactivity
- Mouse, Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PHOX2B antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 15 amino acid synthetic peptide near the center of Human PHOX2B
- Isotype
- IgG
- Top Product
- Discover our top product PHOX2B Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PHOX2B (Paired-Like Homeobox 2b (PHOX2B))
- Alternative Name
- PHOX2B (PHOX2B Products)
- Synonyms
- phox2 antibody, xphox2b antibody, phox2b antibody, PHOX2B antibody, pmx2b antibody, nbphox antibody, NBLST2 antibody, NBPhox antibody, PMX2B antibody, Dilp1 antibody, Pmx2b antibody, paired-like homeobox 2b antibody, paired like homeobox 2b S homeolog antibody, paired-like homeobox 2bb antibody, paired like homeobox 2b antibody, phox2b antibody, phox2b.S antibody, phox2bb antibody, PHOX2B antibody, Phox2b antibody
- Background
- PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons .Synonyms: NBPhox, Neuroblastoma Phox, PHOX2B homeodomain protein, PMX2B, Paired mesoderm homeobox protein 2B, Paired-like homeobox 2B
- Gene ID
- 8929
- NCBI Accession
- NP_003915
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