HHATL antibody (N-Term)

Catalog No. ABIN1450142

Product Details anti-HHATL Antibody

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HHATL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the amino terminus of Human HHATL

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HHATL

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Alternative Name: GUP1 / HHATL (HHATL Products)

Background: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development .Synonyms: C3orf3, Glycerol uptake/transporter homolog, Hedgehog acyltransferase-like protein, KIAA1173, Protein-cysteine N-palmitoyltransferase HHAT-like protein

Gene ID: 57467

NCBI Accession: NP_065758

Pathways: Hedgehog Signaling