2310036D22Rik antibody, 5830455K21Rik antibody, 6430519M21Rik antibody, AI428776 antibody, AI661344 antibody, LRRGT00101 antibody, MGC81788 antibody, tmem106b antibody, zgc:114147 antibody, zgc:64013 antibody, transmembrane protein 106B antibody, transmembrane protein 106B S homeolog antibody, transmembrane protein 106Bb antibody, transmembrane protein 106b antibody, transmembrane protein 106Ba antibody, TMEM106B antibody, Tmem106b antibody, tmem106b.S antibody, tmem106b antibody, tmem106bb antibody, Tsp_02056 antibody, Tsp_01553 antibody, t106b antibody, tmem106ba antibody
Background
Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.Synonyms: Transmembrane protein 106B