GRB10 antibody (C-Term)

Catalog No. ABIN1450124

Product Details anti-GRB10 Antibody

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRB10 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Purification: Affinity Chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the carboxy terminus of Human GRB10

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRB10

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Alternative Name: GRB10 / GRBIR (GRB10 Products)

Synonyms: grb10 antibody, zgc:91987 antibody, GRB10 antibody, grb-10 antibody, grb-ir antibody, irbp antibody, meg1 antibody, rss antibody, LOC100224775 antibody, 5730571D09Rik antibody, AI325020 antibody, Meg1 antibody, mKIAA0207 antibody, RGD1566234 antibody, GRB-IR antibody, Grb-10 antibody, IRBP antibody, MEG1 antibody, RSS antibody, growth factor receptor bound protein 10 antibody, growth factor receptor-bound protein 10a antibody, growth factor receptor bound protein 10 L homeolog antibody, growth factor receptor-bound protein 10 antibody, GRB10 antibody, grb10a antibody, grb10 antibody, grb10.L antibody, LOC100434903 antibody, Grb10 antibody

Background: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts .Synonyms: Grb-IR, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR, KIAA0207

Gene ID: 2887

NCBI Accession: NP_005302

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2