C9ORF116 antibody (N-Term)

Catalog No. ABIN1450123

Product Details anti-C9ORF116 Antibody

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9ORF116 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of Human PIERCE1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for C9ORF116

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Alternative Name: C9orf116 (C9ORF116 Products)

Synonyms: PIERCE1 antibody, RbEST47 antibody, Rbest47 antibody, chromosome 9 open reading frame 116 antibody, RIKEN cDNA 1700007K13 gene antibody, chromosome ssa24 open reading frame, human C9orf116 antibody, chromosome 11 open reading frame, human C9orf116 antibody, C9orf116 antibody, 1700007K13Rik antibody, cssa24h9orf116 antibody, C11H9orf116 antibody

Background: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation (1,2). PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer (3-4). PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies (1-3).Synonyms: Pierce1, p53-induced expression in RB-null cells protein 1

Gene ID: 138162

NCBI Accession: NP_001041730