AFAP antibody (N-Term)
-
- Target See all AFAP (AFAP1) Antibodies
- AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This AFAP antibody is un-conjugated
-
Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of Human AFAP1
- Isotype
- IgG
- Top Product
- Discover our top product AFAP1 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))
- Alternative Name
- AFAP1 (AFAP1 Products)
- Synonyms
- afap antibody, afap-110 antibody, AFAP antibody, AFAP-110 antibody, AFAP110 antibody, 2600003E23Rik antibody, 9630044L16Rik antibody, AI848729 antibody, Afap antibody, mKIAA3018 antibody, actin filament associated protein 1 antibody, AFAP1 antibody, afap1 antibody, Afap1 antibody
- Background
- The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.Synonyms: 110 kDa actin filament-associated protein, AFAP-110, Actin filament-associated protein 1
- Gene ID
- 60312
- NCBI Accession
- NP_940997
-