TMEM59L antibody (C-Term)

Catalog No. ABIN1450042

Product Details anti-TMEM59L Antibody

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59L antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near carboxy terminus of Human TMEM59L

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TMEM59L

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Alternative Name: TMEM59L (TMEM59L Products)

Synonyms: LOC719572 antibody, BSMAP antibody, C19orf4 antibody, 5330410G16Rik antibody, RGD1305557 antibody, transmembrane protein 59 like antibody, transmembrane protein 59-like antibody, TMEM59L antibody, Tmem59l antibody

Background: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.Synonyms: BSMAP, Brain-specific membrane-anchored protein, C19orf4, Transmembrane protein 59-like

Gene ID: 25789

NCBI Accession: NP_036241