BB085247 antibody, F730021E22Rik antibody, Gm1570 antibody, Gm1685 antibody, K2p13.1 antibody, THIK-1 antibody, THIK1 antibody, prdx1 antibody, kcnk13 antibody, si:ch211-173b9.3 antibody, zgc:171694 antibody, potassium channel, subfamily K, member 13 antibody, potassium two pore domain channel subfamily K member 13 antibody, potassium channel subfamily K member 13 antibody, potassium channel, subfamily K, member 13b antibody, potassium channel, subfamily K, member 13a antibody, Kcnk13 antibody, KCNK13 antibody, Tsp_07890 antibody, kcnk13b antibody, kcnk13a antibody
Background
The closely related proteins KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK13 is expressed mainly in the brain, but is also observed in kidneys. KCNK13 has been suggested to be a candidate for the Cs+-permeable K+ channel activated by GABA(B) receptors.Synonyms: KCNK13, Potassium channel subfamily K member 13, THIK-1, Tandem pore domain halothane-inhibited potassium channel 1