FAM193B antibody (N-Term)

Catalog No. ABIN1450012

Product Details anti-FAM193B Antibody

Target: FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM193B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of Human FAM193B

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FAM193B

Target: FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))

Alternative Name: FAM193B (FAM193B Products)

Synonyms: IRIZIO antibody, Kiaa1931 antibody, family with sequence similarity 193 member B antibody, family with sequence similarity 193, member B antibody, FAM193B antibody, Fam193b antibody

Background: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.Synonyms: Family with sequence similarity 193 member B, IRIZIO

Molecular Weight: 99 kDa

Gene ID: 54540

UniProt: Q96PV7