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FAM193B antibody (N-Term)

FAM193B Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1450012
  • Target See all FAM193B products
    FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))
    Binding Specificity
    • 2
    • 1
    N-Term
    Reactivity
    Human
    Host
    • 2
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This FAM193B antibody is un-conjugated
    Application
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid synthetic peptide near the amino terminus of Human FAM193B
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))
    Alternative Name
    FAM193B (FAM193B Products)
    Synonyms
    IRIZIO antibody, Kiaa1931 antibody, family with sequence similarity 193 member B antibody, family with sequence similarity 193, member B antibody, FAM193B antibody, Fam193b antibody
    Background
    FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.Synonyms: Family with sequence similarity 193 member B, IRIZIO
    Molecular Weight
    99 kDa
    Gene ID
    54540
    UniProt
    Q96PV7
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