CMPK2 antibody (C-Term)

Catalog No. ABIN1449968

Product Details anti-CMPK2 Antibody

Target: CMPK2 (Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMPK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the carboxy terminus of Human CMPK2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CMPK2

Target: CMPK2 (Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2))

Alternative Name: CMPK2 (CMPK2 Products)

Background: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory responseSynonyms: LOC129607, UMP-CMP kinase 2

Molecular Weight: 49 kDa

Gene ID: 129607

NCBI Accession: NP_997198

Pathways: Nucleotide Phosphorylation, Cellular Response to Molecule of Bacterial Origin