KPNA7 antibody (N-Term)

Catalog No. ABIN1449957

Product Details anti-KPNA7 Antibody

Target: KPNA7 (Karyopherin alpha 7 (Importin alpha 8) (KPNA7))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA7 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid synthetic peptide near the amino terminus of Human KPNA7

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KPNA7

Target: KPNA7 (Karyopherin alpha 7 (Importin alpha 8) (KPNA7))

Alternative Name: KPNA7 (KPNA7 Products)

Synonyms: KPNA7 antibody, AW146299 antibody, Gm1055 antibody, karyopherin subunit alpha 7 antibody, karyopherin alpha 7 (importin alpha 8) antibody, KPNA7 antibody, kpna7 antibody, Kpna7 antibody

Background: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.Synonyms: Importin alpha 8, Importin subunit alpha-8, Karyopherin alpha 7, Karyopherin subunit alpha-7

Gene ID: 402569

NCBI Accession: NP_001139187

Pathways: Protein targeting to Nucleus