Centriolin antibody (C-Term)
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- Target See all Centriolin (CNTRL) Antibodies
- Centriolin (CNTRL)
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Centriolin antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Mouse, Rat.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 17 amino acid synthetic peptide near the carboxy terminus of Human CCP110
- Isotype
- IgG
- Top Product
- Discover our top product CNTRL Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Centriolin (CNTRL)
- Alternative Name
- CEP110 (CNTRL Products)
- Synonyms
- CEP1 antibody, CEP110 antibody, FAN antibody, bA165P4.1 antibody, Cep1 antibody, Cep110 antibody, 6720467O09Rik antibody, AA968343 antibody, Cntrl antibody, IB3/5 antibody, Ma2a8 antibody, b2b1468Clo antibody, centriolin antibody, CNTRL antibody, Cntrl antibody
- Background
- CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs), disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.Synonyms: CP110, Centrosomal protein of 110 kDa, KIAA0419
- Gene ID
- 9738
- NCBI Accession
- NP_001185951
- Pathways
- M Phase, SARS-CoV-2 Protein Interactome
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