Znf521 antibody, EHZF antibody, Evi3 antibody, B930086A16Rik antibody, zinc finger protein 521 antibody, zinc finger protein 521 S homeolog antibody, Zfp521 antibody, ZNF521 antibody, znf521.S antibody
Background
The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors . ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis .Synonyms: EHZF, Early hematopoietic zinc finger protein, LIP3, LYST-interacting protein 3, Zinc finger protein 521