ATG16L1 antibody (AA 84-114)

Catalog No. ABIN1449612

Product Details anti-ATG16L1 Antibody

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Binding Specificity: AA 84-114

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG16L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Saturated Ammonium Sulfate precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 84~114 amino acids surrounding amino acid L92 of Human APG16L Genename: ATG16L1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-ATG16L1 antibody (ABIN1449612)

Nomura, Uzawa, Yamano, Fushimi, Ishigami, Kouzu, Koike, Siiba, Bukawa, Yokoe, Kubosawa, Tanzawa: "Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis." in: Human pathology, Vol. 40, Issue 1, pp. 83-91, (2008) (PubMed).

Target Details for ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Alternative Name: APG16L / ATG16L1 (ATG16L1 Products)

Synonyms: APG16L antibody, ATG16A antibody, ATG16L antibody, IBD10 antibody, WDR30 antibody, 1500009K01Rik antibody, Apg16l antibody, Atg16l antibody, Wdr30 antibody, atg16 antibody, atg16l antibody, fb57e05 antibody, wu:fb57e05 antibody, zgc:110147 antibody, autophagy related 16 like 1 antibody, autophagy related 16-like 1 (S. cerevisiae) antibody, autophagy related 16-like 1 antibody, autophagy related 16 like 1 S homeolog antibody, ATG16 autophagy related 16-like 1 (S. cerevisiae) antibody, ATG16L1 antibody, Atg16l1 antibody, atg16l1 antibody, atg16l1.S antibody

Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.Synonyms: APG16-like 1, Autophagy-related protein 16-1

Molecular Weight: 68265 Da

Gene ID: 55054

NCBI Accession: NP_001177195

Pathways: Autophagy