CDKN2B antibody

Catalog No. ABIN1449282

Product Details anti-CDKN2B Antibody

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDKN2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: This antibody reacts with p15INK4b (15 kDa).

Cross-Reactivity (Details): Species reactivity (tested):Human (HeLa, 293T, transfectant), does not react with Mouse (NIH/3T3, P3U1) and Rat (PC12, Rat1)

Purification: Protein A agarose

Immunogen: GST-full length human p15INK4b

Clone: 1F6

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Alternative Name: CDKN2B / p15INK4b (CDKN2B Products)

Synonyms: p14-INK4b antibody, cdk4l antibody, ink4b antibody, mts2 antibody, p15 antibody, p15ink4b antibody, tp15 antibody, CDK4I antibody, INK4B antibody, MTS2 antibody, P15 antibody, TP15 antibody, p15INK4b antibody, AV083695 antibody, INK4b antibody, p15(INK4b) antibody, CDKN2A antibody, cyclin dependent kinase inhibitor 2B antibody, Cyclin-dependent kinase 4 inhibitor B antibody, cyclin-dependent kinase inhibitor 2B antibody, cyclin-dependent kinase inhibitor 2B L homeolog antibody, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) antibody, CDKN2B antibody, cdn2b antibody, cdkn2b antibody, cdkn2b.L antibody, Cdkn2b antibody

Background: Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6. p15INK4b is a specific inhibitor of cdk4/cdk6 and is periodically expressed during cell cycle. Induction of p15INK4b is important for TGFß-mediated cytostasis in epithelial cells but not in hematopoietic cells, it may act as an effector of TGF-ß mediated cell arrest.Synonyms: Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2, p14-INK4b, p14INK4b, p15-INK4b

Gene ID: 1030

NCBI Accession: NP_004927

UniProt: P42772

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases