CDKN2B antibody

Catalog No. ABIN1449282

Product Details anti-CDKN2B Antibody

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDKN2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: This antibody reacts with p15INK4b (15 kDa).

Cross-Reactivity (Details): Species reactivity (tested):Human (HeLa, 293T, transfectant), does not react with Mouse (NIH/3T3, P3U1) and Rat (PC12, Rat1)

Purification: Protein A agarose

Immunogen: GST-full length human p15INK4b

Clone: 1F6

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Alternative Name: CDKN2B / p15INK4b (CDKN2B Products)

Background: Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6. p15INK4b is a specific inhibitor of cdk4/cdk6 and is periodically expressed during cell cycle. Induction of p15INK4b is important for TGFß-mediated cytostasis in epithelial cells but not in hematopoietic cells, it may act as an effector of TGF-ß mediated cell arrest.Synonyms: Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2, p14-INK4b, p14INK4b, p15-INK4b

Gene ID: 1030

NCBI Accession: NP_004927

UniProt: P42772

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases