SIPA1 antibody

Catalog No. ABIN1449259

Product Details anti-SIPA1 Antibody

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIPA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: This antibody reacts with human SPA-1.

Purification: Anion exchange column chromatography

Immunogen: Recombinant human SPA-1

Clone: 331-9

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for SIPA1

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Alternative Name: SIPA1 / SPA1 (SIPA1 Products)

Synonyms: Spa1 antibody, SPA1 antibody, signal-induced proliferation-associated 1 antibody, Signal peptidase I (leader peptidase I) antibody, signal-induced proliferation associated gene 1 antibody, SIPA1 antibody, sipA1 antibody, Sipa1 antibody

Background: SPA-1 , signal-induced proliferation associated gene 1, encodes a 130 kDa protein (p130 SPA-1 ) with a domain related to Rap1 GTPase activating protein (Rap1GAP) at the N-terminus and to PDZ protein interaction domain followed by a leucine zipper motif at the C-terminus. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for other small GTPases. p130 SPA-1 was mostly localized at both the plasma membrane and the perinuclear membranous region co-localizing with Rap1 and Rap2. Expression of SPA-1 and rap1GAP genes tended to be segregate in various tissues, lymphoid and hematopoietic tissues expressing abundant SPA-1 transcript without rap1GAP , while those such as brain, kidney and pancreas exhibiting rap1GAP mRNA with little SPA-1.Synonyms: GTPase-activating protein Spa-1, Signal-induced proliferation-associated protein 1, Sipa-1, Spa-1, p130 SPA-1

Gene ID: 6494

NCBI Accession: NP_006738

UniProt: Q96FS4

Pathways: Response to Water Deprivation