PRPF3 antibody

Catalog No. ABIN1449201

Product Details anti-PRPF3 Antibody

Target: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Reactivity: Human, Mouse, Rat, Hamster

Host: Rat

Clonality: Monoclonal

Conjugate: This PRPF3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: This antibody reacts with Prp3.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Hamster, Rat

Purification: Protein G agarose

Immunogen: Human recombinant full-length GSTPrp3

Clone: 4-00E-003

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for PRPF3

Target: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Alternative Name: PRPF3 (PRPF3 Products)

Synonyms: HPRP3 antibody, HPRP3P antibody, wu:fa11f05 antibody, PRPF3 antibody, PRP3 antibody, Prp3p antibody, RP18 antibody, SNRNP90 antibody, 3632413F13Rik antibody, PRP3 pre-mRNA processing factor 3 homolog (yeast) antibody, pre-mRNA processing factor 3 antibody, pre-mRNA processing factor 3 S homeolog antibody, PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) antibody, prpf3 antibody, PRPF3 antibody, prpf3.S antibody, Prpf3 antibody

Background: Retinitis pigmentosa (RP) is an inheritable disease characterized by progressive retinal degeneration and loss of rod photoreceptor cells, leading to total blindness. Recently three genes responsible for autosomal dominant RP (HPRP3, PRPF31, and PRPC8) have been identified as the human orthologues of the yeast genes PRP3, PRP31, and PRP8, respectively. The removal of introns from nuclear pre-mRNAs occurs on spliceosomes, which consist of 4 small nuclear ribonucleoprotein (snRNP) particles and a number of transiently associated splicing factors. All three PRP (pre-mRNA processing factor) genes are involved in the function of the U4/U6,U5 tri-snRNP, the spliceosome component required for the transition to a catalytically active state. In mammals, the 63 kDa HPRP3 is thought to recruit HPRP4 to the U4/U6 snRNP. In yeast, PRP3 and PRP4 genetically interact, and physical interactions between Prp3p and Prp4p proteins are required for association of Prp3p and Prp4p with U4/U6.Synonyms: HPRP3, PRP3, Pre-mRNA-splicing factor 3, U4/U6 small nuclear ribonucleoprotein Prp3, U4/U6 snRNP 90 kDa protein

Molecular Weight: 80 kDa

Gene ID: 9129

NCBI Accession: NP_004689

UniProt: O43395