C18orf1 antibody (AA 1-50) (Cy5)
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- Target See all C18orf1 Antibodies
- C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))
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Binding Specificity
- AA 1-50
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This C18orf1 antibody is conjugated to Cy5
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human C18orf1
- Isotype
- IgG
- Top Product
- Discover our top product C18orf1 Primary Antibody
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))
- Alternative Name
- C18orf1 (C18orf1 Products)
- Synonyms
- C18orf1 antibody, 8230401C20Rik antibody, A430083H02 antibody, A430108L08Rik antibody, D18Ertd653e antibody, D330030L18Rik antibody, low density lipoprotein receptor class A domain containing 4 antibody, LDLRAD4 antibody, Ldlrad4 antibody
- Background
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Synonyms: C18orf1, Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4
Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
- Gene ID
- 753
- UniProt
- O15165
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