INIP antibody (AA 1-50) (Cy5.5)

Catalog No. ABIN1420897

Product Details anti-INIP Antibody (Cy5.5)

Target: INIP (INTS3 and NABP Interacting Protein (INIP))

Binding Specificity: AA 1-50

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INIP antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SOSSC/C9orf80

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for INIP

Target: INIP (INTS3 and NABP Interacting Protein (INIP))

Alternative Name: SOSSC (INIP Products)

Synonyms: C8H9orf80 antibody, C9orf80 antibody, SSBIP1 antibody, INIP antibody, HSPC043 antibody, MISE antibody, SOSSC antibody, hSSBIP1 antibody, 1110054O05Rik antibody, 2610312O17Rik antibody, AA399876 antibody, Ssbip1 antibody, SOSS-C antibody, ssbip1 antibody, zgc:56259 antibody, zgc:86662 antibody, c9orf80 antibody, hspc043-a antibody, mise antibody, sossc antibody, ci080 antibody, INTS3 and NABP interacting protein antibody, ints3 and nabp interacting protein antibody, INTS3 and NABP interacting protein S homeolog antibody, INIP antibody, Inip antibody, inip antibody, inip.S antibody

Background:

Synonyms: INIP, Chromosome 9 open reading frame 80, hSSBIP1, MISE, RP11-276E15.2, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, Single-stranded DNA-binding protein-interacting protein 1, SOSS C, SOSS complex subunit C, SOSS-C, SOSSC, SOSSC_HUMAN, SSB-interacting protein 1, Ssbip1, C9orf80, INTS3- and NABP-interacting protein

Background: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.

Gene ID: 58493

UniProt: Q9NRY2