SLC51B antibody (Cy3)

Catalog No. ABIN1413963

Product Details anti-SLC51B Antibody (Cy3)

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC51B antibody is conjugated to Cy3

Application: Western Blotting (WB)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OST-beta

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLC51B

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Alternative Name: Ost-beta (OSTBETA Products)

Synonyms: Ostb antibody, Ostbeta antibody, RGD1565748 antibody, OSTB antibody, OSTBETA antibody, solute carrier family 51, beta subunit antibody, solute carrier family 51 beta subunit antibody, Slc51b antibody, SLC51B antibody

Background:

Synonyms: organic solute transporter beta Ostbeta, Organic solute transporter subunit beta, Ostbeta, Ost beta, OST-beta, OSTB, OSTB_HUMAN.

Background: The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Gene ID: 123264

Pathways: Regulation of Carbohydrate Metabolic Process